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KMID : 1149220070150020113
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Korean Journal of Oriental Medical Prescription
2007 Volume.15 No. 2 p.113 ~ p.117
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Acute Toxicity Study on Samul-tang(Siwu-tang) in Mice
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Ma Jin-Yeul
Yu Young-Beob
Ha Hye-Kyeong
Hwang Dae-Sun
Ma Choong-Je
Shin Hyeun-Kyoo
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Abstract
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Objectives: Samul-tang(Siwu-tang) has been traditionally prescribed a medicine as a restorative.
Methods: In this study, we investigated the acute toxicity about water-extracted Samul-tang(Siwu-tang). Twenty-five mice completed 14 days of oral Samul-tang(Siwu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg.
Results: We observed survival rates, general toxicity, change of body weight, and autopsy.
Conclusions: Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). LD50 of Samul-tang(Siwu-tang) was over 5000mg/kg and it is very safe to ICR mice.
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KEYWORD
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Samul-Tang(Siwu-tang), Acute toxicity, Safety, LD50
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